Figure 3.

The percentage of prostate glands developed HG-PIN and adenocarcinoma in Pten^p−/−mice fed experimental diet at the age of 6 weeks. (A) At the age of 25 weeks, Pten^p−/− mice fed an AIN93M (n = 8) and a 0.2% δ-T diet (n = 8) from the age of 6 weeks were sacrificed to collect prostate tissues for histopathological characterization. The percentages of prostate glands developing HG-PIN in each lobe of the two groups of mice were scored. Data are presented as mean ± SD. There is no statistical significant difference in the percentage of HG-PIN glands in each lobe between the mice fed an AIN93M and a 0.2% δ-T diet (two-tailed Student’s t-test). (B) At the age of 40 weeks, Pten^p−/− mice fed either an AIN93M (n = 9) or a 0.2% δ-T diet (n = 10) were sacrificed to collect prostate tissues for histopathological characterization. The adenocarcinoma multiplicity (glands developed adenocarcinoma/100 glands counted) in dorsal, ventral and lateral lobes of the two groups of mice are presented in the figure. Data are presented as mean ± SD (*P = 0.0045).