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SphK1 genetic deletion inhibits HER2/neu-indued breast tumorigenesis in mice
| SphK1 genotype | Incidence | Multiplicity | Volume (mm3) |
|---|---|---|---|
| SphK1+/+ | 57% (12/21) | 0.67 ± 0.14 | 2841 ± 1245 |
| SphK1−/− | 19% (5/26)* | 0.27 ± 0.13* | 1185 ± 871 |
The tumor number and volume were recorded at necropsy (35 weeks of age). Values in parentheses represent percentage of mice with tumors. Multiplicity and tumor volume values are mean ± SEM. *P < 0.05 vs. SphK1+/+ (wild-type); Student’s t-test.
