. 2017 Jul 21;38(10):994–1003. doi: 10.1093/carcin/bgx074

Table 5.

Associations between telomere-related SNPs and cancer risk

	SNP	Genotype	Unaffected	Affected	OR	(95%CI)	P	P _trend ^c
				(all cancers)
All participants	rs2736100 (TERT)	CC	99	13	1^a
		CA	155	24	1.18	(0.57, 2.46)	0.66
		AA	91	10	0.9	(0.37, 2.17)	0.81	0.84
	rs1317082 (TERC)	AA	214	30	1^a
		AG	130	18	0.87	(0.45, 1.66)	0.67
		GG	18	6	2.39	(0.88, 6.53)	0.09	0.38
	rs2738783 (RTEL1)	TT	255	43	1^a
		TG	102	11	0.67	(0.33, 1.35)	0.26
		GG	12	2	1.03	(0.22, 4.79)	0.97	0.41
	rs10165485 (ACYP2)	TT	308	42	1^a
		TC	52	12	1.78	(0.87, 3.62)	0.11
		CC	7	1	1.09	(0.13, 9.13)	0.93	0.20
	rs2320615 (NAF1)	GG	203	33	1^a
		GA	144	20	0.91	(0.50, 1.66)	0.75
		AA	24	3	0.82	(0.23, 2.89)	0.76	0.68
	rs9257445 (ZNF311)	GG	206	36	1^a
		GC	141	13	0.48	(0.24, 0.95)	0.035
		CC	22	7	1.58	(0.61, 4.13)	0.35	0.54
	rs6060627 (BCL2L1)	CC	146	29	1^a
		CT	173	22	0.61	(0.33, 1.12)	0.11
		TT	52	5	0.49	(0.18, 1.35)	0.17	0.07
Females only				(all cancers)
	rs2736100 (TERT)	CC	82	7	1^b
		CA	127	21	1.93	(0.79, 4.76)	0.15
		AA	72	9	1.47	(0.52, 4.16)	0.47	0.48
	rs1317082 (TERC)	AA	175	24	1^b
		AG	104	13	0.91	(0.44, 1.87)	0.80
		GG	17	5	2.12	(0.71, 6.27)	0.18	0.43
	rs2738783 (RTEL1)	TT	210	33	1^b
		TG	85	9	0.67	(0.30, 1.45)	0.31
		GG	7	2	1.68	(0.33, 8.59)	0.54	0.65
	rs10165485 (ACYP2)	TT	250	32	1^b
		TC	44	11	1.93	(0.91, 4.12)	0.09
		CC	6	0	N/A	N/A	N/A	N/A
	rs2320615 (NAF1)	GG	171	24	1^b
		GA	110	17	1.10	(0.57, 2.15)	0.77
		AA	22	3	1.0	(0.28, 3.61)	1.00	0.86
	rs9257445 (ZNF311)	GG	170	28	1^b
		GC	115	10	0.53	(0.25, 1.13)	0.10
		CC	16	6	2.27	(0.82, 6.29)	0.12	0.91
	rs6060627 (BCL2L1)	CC	115	24	1^b
		CT	144	17	0.56	(0.29, 1.10)	0.09
		TT	44	3	0.33	(0.09, 1.14)	0.08	0.03
Female only				(breast cancer)
	rs2736100 (TERT)	CC	82	4	1^b
		CA	127	11	1.77	(0.55, 5.76)	0.34
		AA	72	6	1.71	(0.46, 6.32)	0.42	0.43
	rs1317082 (TERC)	AA	175	11	1^b
		AG	104	11	1.68	(0.70, 4.01)	0.24
		GG	17	4	3.74	(1.07, 13.05)	0.039	0.10
	rs2738783 (RTEL1)	TT	210	19	1^b
		TG	85	8	1.04	(0.44, 2.48)	0.93
		GG	7	0	N/A	N/A	N/A	N/A
	rs10165485 (ACYP2)	TT	250	22	1^b
		TC	44	4	1.03	(0.34, 3.18)	0.96
		CC	6	0	N/A	N/A	N/A	N/A
	rs2320615 (NAF1)	GG	171	15	1^b
		GA	110	11	1.14	(0.51, 2.57)	0.75
		AA	22	1	0.52	(0.07, 4.13)	0.54	0.83
	rs9257445 (ZNF311)	GG	170	18	1^b
		GC	115	6	0.49	(0.19, 1.28)	0.15
		CC	16	3	1.77	(0.47, 6.66)	0.40	0.72
	rs6060627 (BCL2L1)	CC	115	15	1^b
		CT	144	10	0.53	(0.23, 1.23)	0.14
		TT	44	2	0.35	(0.08, 1.59)	0.17	0.08

^aAdjusted with age at last interview/diagnosis and gender.

^bAdjusted with age at last interview/diagnosis.

^c P value of the trend test.