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Racially-disparate tumor microenvironment in breast tumors. The TME of BC contains tumor cells, macrophages, dendritic cells, adipocytes, fibroblasts, cytokines and growth factors. Higher vessel density, increased macrophage recruitment and elevated cytokines create differential TME in BC patients of AA racial group. The inflammatory microenvironment induced growth, angiogenesis, metastasis and therapy resistance ultimately leads to poor clinical outcome in AA BC patients.
