Figure 1.

Histopathological appearance of a liver biopsy specimen from a representative patient with non-alcoholic steatohepatitis. (A) Steatosis involves about 35% of hepatocytes in this case: Representative large lipid droplets (macrovesicular steatosis) and small lipid droplets (microvesicular steatosis) are indicated by arrows and arrowheads, respectively. A focus of lobular inflammation (circle) is also observed. Scale bar, 100 μm (hematoxylin and eosin staining). (B) Bridging fibrosis (arrow) and perivenular/pericellular fibrosis (square) are observed. High-power view of the area marked with the square (inset) indicates that hepatocytes (*) are surrounded and downsized by fibrosis. Scale bar, 100 μm (azan staining).