Table 2.

Top 20 statistically significant GO biological processes revealed by MetaCore software analysis using the 275 genes, for which the 375 probes specifically related to NASH-N (listed in Supplementary Table 4, available at Carcinogenesis Online) were designed

Biological process	P value
Protein bindinga	3.777 × 10−7
Molecular function regulator	2.337 × 10−6
Guanyl-nucleotide exchange factor activity	4.976 × 10−5
Actin bindinga	9.468 × 10−5
Structure-specific DNA bindinga	1.027 × 10−4
Macromolecular complex bindinga	1.136 × 10−4
Chromatin bindinga	1.259 × 10−4
Bindinga	1.521 × 10−4
Actin filament bindinga	1.869 × 10−4
Enzyme regulator activity	2.290 × 10−4
Ras guanyl-nucleotide exchange factor activity	3.121 × 10−4
Corticotropin hormone receptor bindinga	3.479 × 10−4
Type 5 melanocortin receptor bindinga	3.479 × 10−4
DNA bindinga	4.297 × 10−4
Chromatin DNA bindinga	4.411 × 10−4
Transcriptional repressor activity, RNA polymerase II activating transcription factor binding	6.468 × 10−4
Transcriptional activator activity, RNA polymerase II transcription factor bindinga	6.468 × 10−4
Core promotor activity	8.838 × 10−4
Enzyme bindinga	1.341 × 10−3
Cytoskeletal protein bindinga	1.540 × 10−3

^aGO biological processes involved in protein–protein binding or binding of proteins to other molecules.