Table 3.
Top 20 statistically significant pathway maps revealed by MetaCore software analysis using the 275 genes, for which the 375 probes specifically related to NASH-N (listed in Supplementary Table 4, available at Carcinogenesis Online) were designed
| Pathway maps | P value |
|---|---|
| Development_NOTCH-induced EMT | 1.408 × 10−7 |
| Development_Notch Signaling Pathway | 1.027 × 10−5 |
| Development_NOTCH1-mediated pathway for NF-KB activity modulation | 2.699 × 10−5 |
| Development_Gastrin in cell growth and proliferation | 6.243 × 10−5 |
| Oxidative stress_ROS-mediated activation of MAPK via inhibition of phosphatases | 8.034 × 10−4 |
| Development_EGFR signaling pathway | 1.198 × 10−4 |
| Development_Thromboxane A2 signaling pathway | 3.674 × 10−4 |
| Development_Oligodendrocyte differentiation from adult stem cells | 3.967 × 10−4 |
| Immune response_T regulatory cell-mediated modulation of effector T cell and NK cell functions | 4.600 × 10−4 |
| Development_Mu-type opioid receptor signaling via Beta-arrestin | 5.635 × 10−4 |
| G-protein signaling_M-RAS regulation pathway | 5.635 × 10−4 |
| Development_Keratinocyte differentiation | 5.682 × 10−4 |
| G-protein signaling_TC21 regulation pathway | 6.372 × 10−4 |
| G-protein signaling_R-RAS regulation pathway | 6.372 × 10−4 |
| Neurogenesis_NGF/ TrkA MAPK-mediated signaling | 7.426 × 10−4 |
| Development_Mu-type opioid receptor regulation of proliferation | 8.944 × 10−4 |
| Immune response_Sublytic effects of membrane attack complex | 1.185 × 10−3 |
| Development_Positive regulation of STK3/4 (Hippo) pathway and negative regulation of YAP/TAZ function | 1.320 × 10−3 |
| Signal transduction_ERK1/2 signaling pathway | 1.328 × 10−3 |
| Reproduction_Gonadotropin-releasing hormone (GnRH) signaling | 1.466 × 10−3 |