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. 2017 Feb 12;38(3):281–292. doi: 10.1093/carcin/bgw121

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Figure 1. — Six1 overexpression increases CRC tumor growth and metastasis in vivo. (A) MC38-Six1 or MC38-Ctrl were orthotopically injected into the cecum subserosa of C57BL/6 mice and mice were killed after 6 weeks. Left panels: tumors from MC38-Ctrl. Right panels: tumors from MC38-Six1. (B) The weight of tumors and tumor incidence in mice injected in the cecum with MC38-Ctrl or isolates of MC38-Six1 cells. (C) Upper panel: livers and spleens from MC38-Six1 tumor-bearing mice. Lower panel: livers and spleens from MC38-Ctrl tumor-bearing mice. (D) The weight of livers (left panel) and spleens (right panel) from MC38-Six1 or MC38-Ctrl tumor-bearing mice. Bars indicate SD, and ** and *** indicate P values <0.01 and <0.001, respectively.