Table 1.
Effect of mouse genotype on incidence and type of spontaneous tumors
| Genotype | Number of mice | Incidence, n (%) | ||||
|---|---|---|---|---|---|---|
| Total | Lymphoma | Adenocarcinoma | Hemangiosarcoma | Histolytic sarcoma | ||
| Wild type | 101 | 8 (7.92) | 5 (4.46) | 0 (0.0) | 0 (0.0) | 3 (2.97) |
| ARH1 −/− | 112 | 25 (22.32)# | 13 (11.61) | 5 (4.46) | 2 (1.79) | 5 (4.46) |
| CD38 −/− | 123 | 1 (0.81)* | 1 (0.81) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
| ARH1 −/−/CD38−/− | 162 | 4 (2.46)* | 2 (1.23) | 0 (0.0) | 0 (0.0) | 2 (1.23) |
Cumulative number and histopathological distribution of spontaneous tumors by genotype.
Pairwise comparisons of tumor incidence were considered as significant at P < 0.05. #P < 0.05 versus wild type, CD38−/− and double knockout; *P < 0.05 versus wild type.