Table 4.
Cox multivariate models examining the association of KDRI and donor age quintiles with the risk of allograft failure in the Canadian cohort after adjustment for differences in recipient and transplant characteristics.
| KDRI model Hazard ratio (95% CI) |
Donor age model Hazard ratio (95% CI) |
|
|---|---|---|
| Quintile | ||
| 0%-20% | 1.00 | 1.00 |
| 21%-40% | 1.18 (0.57-2.44) | 1.14 (0.54-2.38) |
| 41%-60% | 1.45 (0.74-2.84) | 1.65 (0.84-3.23) |
| 61%-80% | 3.05 (1.60-5.80) | 2.45 (1.28-4.71) |
| 81%-100% | 2.73 (1.40-5.31) | 3.13 (1.62-6.07) |
| Age per year | 1.03 (1.02-1.05) | 1.03 (1.02-1.05) |
| Female sex | 0.52 (0.34-0.80) | 0.56 (0.37-0.86) |
| Race | ||
| White | 1.00 | 1.00 |
| Black | NA | NA |
| South Asian | 0.67 (0.38-1.18) | 0.69 (0.39-1.23) |
| East Asian | 0.45 (0.23-0.87) | 0.46 (0.24-0.88) |
| Other | 1.15 (0.67-1.96) | 1.17 (0.68-1.99) |
| Diabetes as cause of ESRD | 1.13 (0.70-1.85) | 1.10 (0.68-0.79) |
| Body mass index (kg/m2) | ||
| <25 | 1.00 | 1.00 |
| 25-29.9 | 1.08 (0.69-1.70) | 1.07 (0.69-1.66) |
| 30-34.9 | 1.04 (0.60-1.81) | 0.99 (0.57-1.72) |
| ≥35 | 1.25 (0.55-2.83) | 1.27 (0.56-2.88) |
| Peak PRA % | ||
| 0 | 1.00 | 1.00 |
| 0.1-30 | 1.55 (0.94-2.56) | 1.44 (0.88-2.38) |
| >30 | 7.08 (4.11-12.19) | 6.78 (3.97-11.57) |
| Pretransplant dialysis (per year) | 1.10 (1.02-1.19) | 1.10 (1.02-1.19) |
| HLA mismatch | ||
| 0-2 | 1.00 | 1.00 |
| 3-4 | 1.59 (0.73-3.47) | 1.72 (0.78-3.78) |
| 5-6 | 1.80 (0.81-4.03) | 1.99 (0.89-4.49) |
| Cold ischemia time hours | ||
| ≤12 hours | 1.00 | 1.00 |
| >12 hours | 1.14 (0.52-2.54) | 1.14 (0.51-2.53) |
Note. KDRI = Kidney Donor Risk Index; CI = confidence interval; HLA = human leukocyte antigen; PRA = panel reactive antibody; ESRD = end-stage renal disease.