Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Jul 26;11:1177625017711414. doi: 10.1177/1177625017711414

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

PMC Copyright notice

Figure 6. — The different VP approaches generate different levels of variability in key pathways of interest. Virtual populations based on the statin responder profile were created using the LIFE (red) and traditional (cyan) VP methods. Variability generated in (A) parameters controlling synthesis and clearance of PCSK9, (B) parameters controlling synthesis and clearance of LDL, and (C) pharmacokinetics-related parameters is shown. Unstable or unphysiological simulations (final LDL > 300 mg/dL) were excluded from plots. LDL indicates low-density lipoprotein; LDLR, low-density lipoprotein receptor; LIFE, Linear-In-Flux-Expressions, VP, virtual patient.