Table 2.

Identified and core parameters defining variability in virtual patients.

Name of flux identified to define variability in virtual patients	Control flux used to set variability in identified flux
Biliary cholesterol secretion rate	Biliary cholesterol secretion rate
Hepatic cholesterol production rate	Hepatic cholesterol production rate
HDL to VLDL exchange rate	HDL to VLDL exchange rate
HDL to LDL exchange rate	HDL to LDL exchange rate
PCSK9 plasma clearance rate	PCSK9 plasma clearance rate
Hepatic intracellular production rate of PCSK9	Rate of hepatic secretion of intracellular PCSK9 into plasma
Hepatic intracellular production rate of LDLR	Rate of peripheral cell intracellular LDLR trafficking to cell surface
Peripheral cell intracellular production rate of LDLR	Rate of hepatic intracellular LDLR trafficking to cell surface
Isolated LDLR degradation rate in hepatic endosomes	Rate of hepatic intracellular LDLR trafficking to cell surface
PCSK9-LDLR dissociation rate in endosomes	PCSK9-LDLR association rate in plasma and PCSK9-LDLR peripheral cell internalization rate
PCSK9-LDLR dissociation rate in plasma	PCSK9-LDLR association rate in plasma and PCSK9-LDLR peripheral cell internalization rate
Isolated LDLR degradation rate in peripheral cell endosomes	Rate of peripheral cell intracellular LDLR trafficking to cell surface

Abbreviations: HDL, high-density lipoprotein; LDL, low-density lipoprotein; LDLR, low-density lipoprotein receptor; VLDL, very low-density lipoprotein.