Skip to main content
. Author manuscript; available in PMC: 2018 Mar 21.
Published in final edited form as: J Alzheimers Dis. 2008 Feb;13(1):71–80. doi: 10.3233/jad-2008-13108

Fig. 1. SP1 consensus sites on human, rhesus and cynomolgus monkey, and rat APP promoter sequences.

Fig. 1

Available sequences for human (GenBank #D87675), rhesus (GenBank #AF067971), cynomolgus (GenBank #M58727) and rat (RGSC v3.4) APP promoter sequences from -1000 bases upstream of the +1 transcription start site to the translation start “ATG” were scanned with the “TESS” utility [40] for the presence of SP1 consensus sequences at 95% minimum homology. Sites are indicated on the respective sequences. (A) Human sequence, experimentally-validated sites are indicated at positions -57/-52 [35], +54/+59 [8], and +63/+83 [50]. (B) Rhesus monkey sequence, (C) Available cynomolgus monkey sequence, (D) Rat sequence. Experimentally-validated SP1 site at -215/-206 [16] is indicated.