Table 1. Morphological parameters in histology, optical coherence tomography, and quantitative angiography.
| Saline (N = 11) | HMGB1 (N = 11) | TNF-α (N = 10) | |
|---|---|---|---|
| Histology | |||
| Media, mm2 | 1.13±0.13 | 1.10±0.26 | 1.21±0.19 |
| Intima, mm2 | 0.32±0.03 | 0.69±0.11* | 0.79±0.18* |
| Plaque, mm2 | 1.45±0.15 | 1.80±0.36 | 2.00±0.28 |
| I/P*100 (%) | 23.11±1.56 | 40.28±1.78* | 37.90±5.49* |
| OCT | |||
| Vessel area, mm2 | 13.52±1.43 | 14.53±0.67 | 15.82±1.59 |
| Lumen area, mm2 | 8.72±0.98 | 7.76±0.50 | 9.34±1.21 |
| Plaque, mm2 | 4.81±0.56 | 6.77±0.27* | 6.49±0.53* |
| Area stenosis, % | 35.53±1.54 | 46.43±1.20* | 42.64±3.08* |
| Lipid rich plaque, % | 2/11 (18%) | 9/11 (82%) | 5/10 (50%) |
| QCA | |||
| RD, mm | 3.23±0.20 | 3.01±0.41 | 3.33±0.32 |
| MLD, mm | 2.55±0.18 | 2.11±0.33 | 2.32±0.27 |
| DS, % | 21.28±0.74 | 30.51±1.68* | 31.71±2.47* |
Values are n (%) or mean ± SEM. QA, quantitative angiography; OCT, optical coherence tomography; RD, reference diameter; MLD, minimal luminal diameter; DS, diameter stenosis; and I/P, intimal plaque ratio.
*p<0.05, compared with the Saline group