Fig 2. CCX872 improves renal function as assessed by UACR, serum creatinine and BUN in adriamycin challenged mice.

Mice were challenged with Adriamycin as described in Methods. Test compound treatment was begun one hour prior to the Adriamycin challenge. Urine was collected for measurement of UAER (S3 Table) and creatinine at the indicated time points, and UACR was calculated as described in Methods. Serum creatinine and BUN were measured at time of terminal bleed after two weeks of treatment. Error bars represent standard error of the mean. N = 10/group at week 1, and N = 8 at week 2. p values were calculated on each treated group to vehicle treated animals using student’s t-test (GraphPad Prism).