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. 2018 Mar 21;13(3):e0192405. doi: 10.1371/journal.pone.0192405

Fig 3. CCX872 improves renal function as assessed by UACR, serum creatinine, BUN and cystatin C in 5/6 nephrectomized mice.

Fig 3

Mice underwent a 5/6 nephrectomy as described in Methods. Three weeks post-surgery the mice were randomized to the groups indicated above for the study period of 4 weeks. Urine was collected for measurement of albumin and creatinine at the indicated time points, and UACR was calculated as described in Methods. Serum creatinine, BUN and Cystatin C were measured at time of terminal bleed after four weeks of treatment. Error bars represent standard error of the mean. N = 10/group, and N = 6 at week 3. p values were calculated between each drug-treated group and vehicle treated animals (asterisk), or between CCX872/RAAS blocker combination and RAAS blocker alone (octothorpe) using student’s t-test (GraphPad Prism).