Fig 5. Effect of ECM composition and mechanical properties on growth-induced stress.

(A) Collagen or (B) hyaluronan (HA) area fraction is not associated with growth-induced stress, whereas a relation seems to exist when (C) the ratio of HA/collagen area fraction is employed. (D) Growth-induced stress does not depend on tumor opening but there is a good correlation between growth-induced stress and tumor elastic modulus (E) as well as with the product of tumor opening and elastic modulus (F). Error bars represent the range of estimated growth-induced stress.