Table 2. List of 30 miRNAs that were upregulated in S1 and T4-2 revertants and downmodulated in T4-2 in lrECM (p-value<0.05 was considered significant).

Mature ID	Fold regulation S1 vs T4-2	Fold regulation T4 rev vs T4	P value
miR-450b-5p	30.3789	869.8262	0.049943
miR-105	11.1967	783.9313	0.007486
miR-383	52.5275	735.6709	0.042511
miR-432	17.7736	541.6623	0.020574
miR-495	455.6135	510.0813	0.004495
miR-30e	65.4581	228.7297	0.047957
miR-190	48.2236	221.0022	0.044772
miR-369–3 p	14.1069	158.4536	0.041128
miR-323–3 p	13.8486	118.1588	0.015214
miR-127–5 p	10.5195	115.9948	0.005194
miR-330–3 p	39.2603	113.8705	0.044612
miR-382	24.6754	82.0207	0.021385
miR-337–3 p	36.2104	35.2915	0.003663
miR-423–3 p	55.2984	32.9948	0.045694
miR-125b	48.925	29.9434	0.04939
miR-376a	212.9199	11.2032	0.049943
miR-296–5 p	42.5671	8.5618	0.045775
miR-135a	60.0253	7.5379	0.045617
miR-144	1234.0342	7.3743	0.003973
miR-301b	32.1668	7.1892	0.043739
miR-376c	49.8377	6.2803	0.046834
miR-487a	68.5143	6.2243	0.035722
miR-590–3 p	14.4952	5.9622	0.035266
miR-301a	30.8564	5.4045	0.047854
miR-98	33.6103	5.1012	0.041169
miR-34c-5p	31.215	4.8038	0.043702
miR-496	42.8632	3.2108	0.044913
miR-543	74.4569	2.897	0.01967
miR-143	590.5164	2.2076	0.042274
miR-374a	11.1001	1.1926	0.013047