Table 3. List of 12 miRNAs that were upregulated in S1 and T4-2 revertants and downmodulated in T4-2, and that could target more than 10 genes among the 60 genes that showed the opposite expression patterns.
| Mature ID | Fold regulation T4 vs Control |
Fold regulation T4 Rev vs T4 |
p-value | # Targets / 60 genes |
Gene locus | Type | |
|---|---|---|---|---|---|---|---|
| miR-450b-5p | −30.3789 | 869.8262 | 0.000304 | 15 | Xq26.3 | Intergenic | |
| miR-495 | −455.6135 | 510.0813 | 0.028964 | 12 | 14q32.31 | Intergenic | |
| miR-30e* | −65.4581 | 228.7297 | 0.008983 | 11 | 1p34.2 | Intronic | Down (p<0.05) |
| miR-330–3 p | −39.2603 | 113.8705 | 0.007481 | 22 | 19q13.32 | Intronic | |
| miR-382 | −24.6754 | 82.0207 | 0.001901 | 12 | 14q32.31 | Intergenic | |
| miR-423–3 p | −55.2984 | 32.9948 | 0.011304 | 14 | 17q11.2 | Intronic | |
| miR-135a | −60.0253 | 7.5379 | 0.039409 | 13 | 3p21.1 | Intergenic | |
| 12q23.1 | Intergenic | ||||||
| miR-144* | −1234.0342 | 7.3743 | 0.010599 | 12 | 17q11.2 | Intergenic | Down (p<0.05) |
| miR-301b | −32.1668 | 7.1892 | 0.028553 | 16 | 22q11.21 | Intergenic | |
| miR-590–3 p | −14.4952 | 5.9622 | 0.043351 | 21 | 7q11.23 | Intronic | |
| miR-301a | −30.8564 | 5.4045 | 0.044539 | 13 | 17q22 | Intronic | |
| miR-34c-5p* | −31.215 | 4.8038 | 0.01567 | 10 | 11q23.1 | Intergenic | Down (0 < 0.05) |
*The three miRNAs in bold that were the focus of this study.
†p-values were obtained from the array results [GSE2564] (Petersen et al., 1998).