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. 2018 Jan 8;10:438–449. doi: 10.1016/j.omtn.2018.01.001

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© 2018 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

In Vivo Antitumor Effects of 188Re-U2

(A) The in vivo effectiveness of 188Re-U2 was evaluated in xenograft murine models bearing tumors originating from U87-EGFRvIII cells. (I) Blank control group. (II) 188Re: dissociate radionuclide 188Re group. (III) 188Re-GN: 188Re-labeled original library GN group. (IV) 188Re-U2: 188Re-labeled aptamer U2 group. (B) The tumor size before and after injecting drugs. (C) The tumor weight that had been stripped (n = 9). *p < 0.01 compared with the blank group; ^#p < 0.01 compared with the 188Re radionuclide group; ^&p < 0.01 compared with the 188Re-GN group; and P, p < 0.05 compared with the blank group.