Table 3  Thrombophilia and risk of RSA based on meta-analyses.

Thrombophilia	RSA overall	RSA in the 1st trimester	Non-recurrent miscarriage in the 2nd trimester	Non-recurrent late miscarriage
The confidence interval for the odds ratio was set at 95%. RSA: recurrent spontaneous abortion; late miscarriage = pooled miscarriages after the 10th 10 , 20th 27 or 24th GW 28 ; FVL: factor V Leiden mutation; PGM: prothrombin gene (G20210A) mutation; MTHFR: methylene tetrahydrofolate reductase C677T mutation; APC resistance: active protein C resistance. Anticardiolipin antibodies: IgG 13 ,  28 , IgG/IgM 10 . β2-glycoprotein I antibodies: IgG 13 , IgG/IgM 10 .
Lupus anticoagulant	15.42 (5.90 – 40.38) 13	n. s.	14.28 (4.72 – 43.20) 28	2.30 (0.81 – 6.98) 28	10.59 (1.87 – 59.88) 10
Anticardiolipin antibodies	3.57 (2.26 – 5.65) 13	5.05 (1.92 – 14.01) 28	n. s.	3.30 (1.62 – 6.70) 28	4.29 (1.34 – 13.68) 10
β2-glycoprotein I antibodies	n. s.	2.12 (0.69 – 6.53) 13	n. s.	23.46 (1.21 – 455.01) 10
FVL (homozygous and heterozygous)	3.04 (2.16 – 4.3) 27	1.91 (1.01 – 3.61) 28	4.12 (1.93 – 8.81) 28	3.26 (1.82 – 5.83) 27	2.06 (1.1 – 3.86) 28
Heterozygous PGM G20210A	2.05 (1.18 – 3.54) 27	2.70 (1.37 – 5.34) 28	8.6 (2.18 – 33.95) 28	2.3 (1.09 – 4.87) 27	2.66 (1.28 – 5.53) 28
Protein S deficiency	14.72 (0.99 – 218.01) 27	n. s.	n. s.	7.39 (1.28 – 42.83) 27	20.09 (3.7 – 109.15) 28
Protein C deficiency	1.57 (0.23 – 10.54) 27	n. s.	n. s.	3.05 (0.24 – 38.51) 27
Antithrombin deficiency	0.88 (0.17 – 4.48) 27	n. s.	n. s.	7.63 (0.30 – 196.36) 28
Homozygous MTHFR 677 T	0.98 (0.55 – 1.72) 27	0.96 (0.44 – 1.69) 28	n. s.	1.31 (0.89 – 1.91) 28
APC resistance	n. s.	2.60 (1.21 – 5.59) 28	n. s.	0.98 (0.17 – 5.55) 28