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. 2017 Nov 28;9(17):13154–13166. doi: 10.18632/oncotarget.22743

Figure 4. Inhibition of DYRK1B by kinase inhibitor AZ191 or RNAi impairs motility in liposarcoma cell lines.

Figure 4

(A) Representative migration images of SW872 cell lines at different time points (0, 8, 24, and 48 hours) when treated with different concentrations of AZ191. Original magnification: 100×. Scale bar = 100 μm. (B) Relative migration distance of SW872 and SW982 at different time points (0, 8, 24, and 48 hours) when treated with different concentrations of AZ191. (C) Relative migration distance of SW872 and SW982 at different time points (0, 8, 24, and 48 hours) when treated with different concentrations of DYRK1B siRNA and non-specific siRNA. (D) Confirmation of relative migration distance of SW872 and SW982 at different time points (0, 8, 24, and 48 hours) when treated with different concentrations of DYRK1B esiRNA and non-specific siRNA. (E and F) Representative invasion images and number of invasion SW872 cells through the Matrigel after treatment with DMSO or AZ191 3 μM for 48 hours. Original magnification: 200×. Scale bar = 50 μm. Data were shown as means ± S.D.