Figure 1. Phthalate treatment upregulated drug resistance- and anti-apoptosis-related proteins in HCT116 and SW480 cells.
Cells were incubated with or without DEHP or MEHP (10 μM) for 0, 24, 48, or 72 h. Western blotting results showed that P-glycoprotein, CD133, and Bcl-2 levels, and the Bcl-2/Bax ratio were increased in treated cells. (−) indicates cells grown without DEHP/MEHP treatment.