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. 2018 Jan 11;9(17):13193–13205. doi: 10.18632/oncotarget.24149

Figure 1. EIF3C is overexpressed and associated with poor patient survival in multiple HCC cohorts.

Figure 1

(A) EIF3C RNA expression is higher in tumor than that of normal tissues in TCGA dataset (Unpaired t test). (B) Higher expression of EIF3C is associated with poor survival than lower expression of EIF3C in TCGA HCC dataset. (Log-rank (Mantel-Cox) test). (C) EIF3C expression is upregulated during HCC tumor progression (Probe:200647_x_at, iCOD dataset) (Bartlettʼs test). (D) EIF3C overexpression is associated with poor patient survival (Probe:200647_x_at, iCOD dataset). (Log-rank (Mantel-Cox) test). (E) Representative EIF3C protein expression level in normal and tumor sample in tissue arrays for scoring from 0 to 3 by immunohistochemistry (IHC) assays. (F) EIF3C protein expression distribution in normal and tumor tissues after IHC scoring from 0 to 3. (G) Higher protein expression of EIF3C (IHC score: 3, n = 57) is associated with poor survival in compared to lower expression of EIF3C (IHC score: 0, 1 and 2, n = 72) in HCC tumor tissues in tumor tissue arrays. (Log-rank Mantel-Cox test).