Table 2. Best model for effect of independent variables (coefficients) and selected interactions on relative telomere length.
| Best Model: histological status + age, sex, smoking + interactions sex, smoking with age | ||||
|---|---|---|---|---|
| Coefficients: | ||||
| Estimate | Std. Error | t value | P-value | |
| (Intercept) | 0.980710 | 0.021214 | 46.229 | < 2 x 10-16 *** |
| CRC | 0.079773 | 0.017166 | 4.647 | 3.61 x 10-6 *** |
| High-risk adenoma | 0.026909 | 0.014274 | 1.885 | 0.05956. |
| Low-risk adenoma | 0.027596 | 0.014207 | 1.942 | 0.05224. |
| Age | -0.012486 | 0.001487 | -8.398 | < 2 x 10-16 *** |
| Sex male | -0.051949 | 0.011790 | -4.406 | 1.11 x 10-5 *** |
| Former smoker | 0.015836 | 0.019358 | 0.818 | 0.41344 |
| Never smoker | 0.048524 | 0.018723 | 2.592 | 0.00963 ** |
| Age:Sex male | 0.001750 | 0.001095 | 1.597 | 0.11033 |
| Age:former smoker | 0.003296 | 0.001603 | 2.055 | 0.03998 * |
| Age:never smoker | 0.003370 | 0.001514 | 2.226 | 0.02613 * |
Significance codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1.
Residual standard error: 0.229 on 1832 degrees of freedom.
Multiple R-squared: 0.1564, Adjusted R-squared: 0.1518.
F-statistic: 33.97 on 10 and 1832 DF, p-value: < 2.2 x 10-16.
The model includes main effects for histological status group, age, sex and smoking status plus two-way interactions between age and sex and age and smoking, respectively. Interactions with histological status were not significant and were therefore not included in the model.