Table 1. Characteristics of studies included in the meta-analysis.
| First Author | Year | Country | No. of patients | Age Median (range) (years) |
IHC evaluation method |
Antibody | Cutoff | PD-L1 positive (%) | Follow-up Median (range) (months) |
Quality Assessment (score) |
|||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Company | Source | Clone | Dilution | ||||||||||
| Chen, K | 2016 | China | 536 | 63 (46–73) |
Percentage | Sigma-Aldrich | Rabbit | SAB2900365 | 1:400 | ≥5% | 41.4% (222/536) | 32.7 (1.0–88.7) |
7 |
| Chen, L | 2014 | China | 99 | 59 | H-score | Novus Biologicals | Rabbit | NBP1-03220 | 1:200 | >0 | 82.8% (82/99) | NA | 7 |
| Chen, MF | 2016 | China (Taiwan) |
162 | NA | IRS score | R&D Systems or Biolegend | NA | NA | NA | ≥ 2 | 45% (74/162) |
NA | 6 |
| Hatogai | 2016 | Japan | 196 | 65 (42–87) |
Percentage | Cell Signaling Technology | Rabbit | E1L3N | 1:400 | ≥ 1% | 18.4% (36/196) |
66 (1.2–127.2) |
8 |
| Jesingha-us | 2017 | Germany | 125 | 60 (39–83) |
Percentage | NA | NA | SP263 | 1:400 | ≥ 10% | 30.4% (38/125) |
65.09 | 8 |
| Jiang, D | 2017 | China | 278 | 62 (37–82) |
Percentage | OriGene Technologies | Rabbit | SP142 | 1:300 | ≥ 5% | 45% (125/278) |
33 (2–102) |
8 |
| Jiang, Y Cohort A | 2016 | China | 250 | NA | Percentage | Merck KGaA | Rabbit | 73-10 | 1:1000 | ≥ 1% | 78.4% (196/250) |
34.4 (0.3–147.1) |
7 |
| Jiang, Y Cohort B | 2016 | China | 78 | NA | Percentage | Merck KGaA | Rabbit | 73-10 | 1:1000 | ≥ 1% | 80.8% (63/78) |
34.4 (0.3–147.1) |
7 |
| Kim | 2016 | South Korea | 200 | 65 (41–83) |
H-score | Cell Signaling Technology | Rabbit | E6H4 | NA | ≥ 1 | 33.5 (67/200) |
33.2 (0.6–178.7) |
8 |
| Leng | 2016 | China | 106 | 59 (38–80) |
H-score | Abcam | Rabbit | ab58810 | 1:40 | ≥ 3 | 46.2% (49/106) |
55 | 6 |
| Tanaka | 2016 | Japan | 180 | 64 (29–84) |
IRS score | Woburn | mouse | 27A2 | NA | ≥ 4 | 29.4% (53/180) |
24 (1–196) |
7 |
| Tsutsumi | 2017 | Japan | 90 | 62.7 | Percentage | Lifespan Bioscience | Rabbit | NA | 1:200 | > 5% | 63.3% (57/90) |
NA | 6 |
| Zhang | 2017 | China | 344 | NA | Percentage | Spring Bioscience | Rabbit | SP142 | NA | > 5% | 14.5% (50/344) |
NA | 6 |
| Zhu | 2017 | China | 133 | NA | Percentage | Beijing Zhongshan Golden Bridge Biotechnology | Rabbit | SP142 | NA | > 5% | 51.1% (68/133) |
42.6 | 6 |