Fig. 5.

Perivascular Spaces and Lacunar Infarcts. An example of a juxtacortical, enlarged perivascular space (PVS) mimicking a cerebral microinfarct (CMI), in a post-mortem brain of a 68-year-old female with Alzheimer's Disease pathology (BB VI) and severe cerebral amyloid angiopathy, identified on (A) T2-weighted ex vivo MR-imaging (repetition time 3500 ms, echo time 164 ms, acquired voxel size 0.4×0.4×0.4 mm³, no SENSE acceleration, scan duration 112 min) and with (B) histopathological correlation, Hematoxylin & Eosin (H&E) staining. (A) The small hyperintense enlarged PVS is located in juxtaposition to the cortex (white arrow). (B) No evidence of neuronal death or gliosis is seen on H&E (black arrow). (images courtesy of S.J. van Veluw).