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Proton treatment plan for a primary brain tumor patient with a prescribed dose of 60 Gy(RBE) to the CTV. (A) Absorbed physical dose Dphys; (B) LET distribution; (C) variable RBE distribution based on measured in vitro RBE data [7], which depend on dose and LET; (D) difference in RBE-weighted dose: Dphys × RBE − Dphys × 1.1. Courtesy of Jan Eulitz and Christian Hahn.
