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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: Addict Biol. 2017 Sep 22;23(5):1117–1129. doi: 10.1111/adb.12568

Figure 1. Cortico-striatal connectivity involved in drug-cue associations and extinction learning.

Figure 1

The medial prefrontal cortex (mPFC) can be subdivided into dorsal (dPFC) and ventral (vPFC) regions. The dPFC receives input from the basolateral amygdala, and projects to the dorsal striatum (DS) and nucleus accumbens core (NAcC) to facilitate drug-cue associations. The vPFC integrates input from the basolateral amygdala, hippocampus, and dorsal hypothalamus and primarily projects to the nucleus accumbens shell (NAcS) to facilitate extinction learning. For a more detailed discussion, please see the following reviews that address cortico-striatal connectivity and its importance in modulating drug-induced plasticity (Gass and Chandler, 2013; Gourley and Taylor, 2016; Peters et al., 2009).