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. Author manuscript; available in PMC: 2019 Mar 21.
Published in final edited form as: J Hepatol. 2017 Sep 21:S0168-8278(17)32291-2. doi: 10.1016/j.jhep.2017.09.010

Fig. 6. Adoptive transfer of ST2 KO neutrophils in WT neutrophil-depleted mice resulted in protective effects after liver I/R.

Fig. 6

(A) Serum MPO-DNA levels and tissue cit-H3 protein levels were measured. Adoptive transfer of ST2 KO neutrophils resulted in significantly fewer circulating MPO-DNA and lower cit-H3 expression compared to WT mice receiving adoptive transfer of WT neutrophils. (B) Significantly reduced serum ALT levels indicated reduced liver injury in adoptively transferred ST2 KO neutrophils mice. (C) During liver I/R, DAMP IL-33 released from damaged LESCs, acts in a paracrine manner on ST2-expressing neutrophils to form NETs. Formation of NETs during I/R propagate hepatotoxicity and systemic inflammation.