Fig. 5.
OrthomAb boosts cytokine secretion by anti-CD3-stimulated T cells. B6 splenocytes (1 × 105) were cultured with soluble anti-CD3 at 15 ng/ml (a), 0, 5 or 20 ng/ml (b) or 20 ng/ml (c) plus the indicated concentrations of costimulators for 48 (a, c) or 24 h (b). Significance between OrthomAb and anti-CD134 or -CD137 are indicated by * and #, respectively (a, b), and between OrthomAb and unlinked anti-CD134 plus -CD137 indicated by * (c). N = 3 in each panel, which are representative of multiple similar trials