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. Author manuscript; available in PMC: 2019 Mar 21.
Published in final edited form as: ACS Chem Neurosci. 2017 Nov 21;9(3):514–521. doi: 10.1021/acschemneuro.7b00309

Figure 3.

Figure 3

Effects of pretreatment with the bivalent derivative 6c. Rats (n=7–8/group) were treated (i.p.) with vehicle (Veh) or bivalent ligand 6c (2 mg/kg) 30 min prior to injection with saline (Sal; 1 ml/kg) or cocaine (Coc; 15 mg/kg) immediately before the test session commenced. Data are presented as mean (± SEM) total horizontal ambulation [A] or vertical activity counts [B] summed across the entire 90 min session. Total horizontal ambulation [C] and vertical activity [D] in 5-min time bins are presented.