Table 1.

Potency of M100907 derivatives on ERK_1/2 activation in h5-HT_2AR-CHO cells.^a

ID	Linker #	pIC50 ± SEM	IC50 (nM)
1	—	8.29 ± 0.52	5.1
2	—	N.T.	N.T.
3	—	N.T.	N.T.
4	—	8.00 ± 0.05	10.1
5a	10	8.11 ± 0.51	7.9
5b	13	6.65 ± 0.04	225
6a	5	6.53 ± 0.24	298
6b	8	7.59 ± 0.53	25.6
6c	11	6.75 ± 0.16	178
6d	14	7.01 ± 0.13	98.2
6e	17	6.78 ± 0.39	164
6f	20	6.55 ± 0.12	284
6g	23	6.72 ± 0.14	192

^apIC₅₀ is presented as mean ± SEM (n = 3–6). IC₅₀ values were calculated from averaged pIC₅₀ values.

“—” indicates that there is no atom linker on this compound. “NT” indicates compound has not been tested in this assay.