Table 3. Population parameter estimates obtained using the PK/VK model.
For the PK, the additive error is a1=5.38 ng/mL (RSE=5%) and the proportional error b=0.15 (RSE=4%). For the VK, additive error is a2=0.20 log10 UI/mL (RSE=7%).
| Parameter (unit) |
Tlag (hr) |
ka (hr−1) |
Vc (L) |
ke (/hr) |
k12 (/hr) |
k21 (/hr) |
Emax | EC50 (μg/mL) |
h |
V0 (log10 IU/mL) |
c (d−1) |
δ (d−1) |
|||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1a | 1b | 1a | 1b | 1a | 1b | ||||||||||
| Estimates (R.S.E. %) | 1.68 (8) | 0.26 (19) | 5.11 (17) | 0.063 (17) | 0.12 (28) | 0.07 (11) | 0.997 (~0) | 17.8 (19) | 8.45 (16) | 3.46 (12) | 15.6 (19) | 6.35 (2) | 3.86 (12) | 6.98 (6) | 0.0933 (52) |
| IIV % (R.S.E. %) | 52 (12) | 42 (16) | 21 (18) | 21 (21) | 60 (14) | 42 (25) | - | 45 (19) | 10 (158) | 9 (14) | 14 (42) | 167 (24) | |||