Skip to main content
. 2018 Mar 15;9:373. doi: 10.3389/fimmu.2018.00373

Figure 4.

Figure 4

Trib1 overexpression in B cells induces a decrease of autoantibody production in a LPS-induced lupus mouse model. (A) Sera from 3-month-old and 6-month-old Trib1-ROSA and Trib1-ROSA Mb1Cre mice were collected and basal anti-dsDNA IgM autoantibody titers were determined by ELISA. (B) 3-month-old Trib1-ROSA and Trib1-ROSA Mb1Cre mice were injected with PBS or LPS (at days 0, 7, and 14) and bleeded every week until day 28. The titers of anti-dsDNA IgM at day 28 were measured by ELISA. Because results were not different between PBS-injected Trib1-ROSA and Trib1-ROSA Mb1Cre mice, these mice were pooled on the PBS-injected control group. Each dot represents the result for one animal (*p < 0.05, Mann and Whitney test).