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. 2018 Mar 15;9:373. doi: 10.3389/fimmu.2018.00373

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Copyright © 2018 Simoni, Delgado, Ruer-Laventie, Bouis, Soley, Heyer, Robert, Gies, Martin, Korganow, San Martin and Soulas-Sprauel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Trib1 overexpression in B cells induces a decrease of Erk phosphorylation after BCR engagement. Purified mature splenic B cells (CD43⁻) from Trib1-ROSA and Trib1-ROSA Mb1Cre mice were stimulated with anti-IgM (10 µg/mL) for the indicated time. Cell lysates were analyzed by western blot using anti-phospho Erk antibody (P-Erk). Total Erk was used as a loading control. The ratio of phospho-p42/Total p42 was calculated for each condition and represented in (A). Each dot is representative of one mouse. Representative immunoblots of the indicated stimulation timepoints are presented in (B). (US: unstimulated) (*p < 0.05, Mann and Whitney test).