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. 2018 Mar 15;9:548. doi: 10.3389/fimmu.2018.00548

Figure 1.

Figure 1

Hypothetical diverse roles of CD1d-restricted type II NKT cells that recognize endogenous hydrophobic peptides. (A) Preceding inflammation sometimes results in the injury of own tissues. Under such situation, injured cells then present hydrophobic autoantigens, probably peptides, on their CD1d to activate CD1d-restricted type II NKT cells. Thereafter, activated CD1d-restricted type II NKT cells function to diminish inflammation by producing anti-inflammatory cytokines and by inducing apoptosis of effector cells via Fas/FasL interaction. (B) When CD1d-restricted type II NKT cells activated by endogenous hydrophobic peptides produce pro-inflammatory cytokines, the inflammation is exacerbated.