FIGURE 3.

(A) Effect of CBiPES (1–10 mg/kg) on head twitches induced by DOI in mGlu₃ receptor KO mice for 30 min following drug administration. CBiPES was administered 30 min prior to DOI. Each bar represents the mean (±SEM) of eight animals after i.p. dosing. Significantly different from 0 or the vehicle condition, ^∗p < 0.05. Significantly different from 0 (vehicle) by the Fishers Exact Test, ^#p < 0.05. (B) Effect of LY379268 (1 mg/kg) on head twitches induced by DOI in mGlu₃ receptor KO mice for 30 min following drug administration. LY379268 was administered 30 min prior to DOI. Each bar represents the mean (±SEM) of eight animals after i.p. dosing. Significantly different from respective WT, ^∗p < 0.05 or KO, ^∗∗∗p < 0.05 treated only with DOI. Significantly different from respective WT and KO treated only with DOI by Fishers Exact Test, ^#p < 0.05. (C) The effect of LY341495 (1–10 mg/kg) on head twitches induced by DOI in mGlu₃ receptor KO mice for 30 min following drug administration. LY341495 was administered 30 min prior to DOI. Each bar represents the mean (±SEM) of 16 animals after i.p. dosing. Significantly different from DOI alone (“0” condition in the figure), ^∗p < 0.05.