FIGURE 4.

(A) The effect of vehicle or CBiPES (10–30 mg/kg) on head twitches induced by the administration of DOI (3 mg/kg) and LY341495 (3 mg/kg) in CD-1 WT mice for 30 min following drug administration. CBiPES was administered 5 min prior to LY341495, which was administered 30 min prior to DOI. Each bar represents the mean (±SEM) of eight animals after i.p. dosing. (B) The effect of vehicle or CBiPES (30 mg/kg) on head twitches induced by DOI (3 mg/kg), with or without the presence of LY341495 (3 mg/kg), in WT and mGlu₃ receptor KO mice for 30 min following drug administration. Each bar represents the mean (±SEM) of eight animals after i.p. dosing. KO-LY341495 significantly different from KO without LY341495, ^∗p < 0.05 or KO-DOI-LY341495-CBiPES significantly different from KO-DOI-LY341495, ^∗p < 0.05.