Table 7.

Results of meta-analysis of SCAN1 and replication cohorts

SNP	CHR	BP	A0	A1	Study	HG	CONTROL	OR	95% CI	p-value	Het p
						A1 Freq	A1 Freq
rs16982345	chr19	18500722	A	G	SCAN1	0.8	0.73	1.47	[1.33, 1.63]	6.81E−15	–
					HG-IV	0.83	0.75	1.63	[1.35, 1.98]	2.80E−07	–
					HG-TPN	0.82	0.74	1.61	[1.01, 2.60]	4.00E−02	–
					META	–	–	1.5	[1.38, 1.65]	2.12E−19	6.62E−01
rs4865234	chr4	58355015	G	A	SCAN1	0.7	0.64	1.32	[1.20, 1.43]	7.95E−10	–
					HG-IV	0.72	0.66	1.43	[1.16, 1.79]	9.00E−04	–
					HG-TPN	0.75	0.63	1.82	[1.20, 2.70]	2.81E−03	–
					META	–	–	1.33	[1.23, 1.62]	9.29E−12	7.27E−01

A1 is the allele associated with increased risk of HG