Fig. 3.

Microgliosis and ZIKV RNA in ZIKV-infected, wild-type mouse brains treated with MAb-5A3. a–c Brain sections were examined by hematoxylin and eosin, which showed a minimal microgliosis at day 3 PI (arrows), b minimal-to-mild microgliosis at day 6 PI (arrows), and c moderate microgliosis at day 10 PI (circle). Scale bar represents 100 μm. d–f Representative images of ISH staining of ZIKV RNA in the brains of MAb-5A3-treated, ZIKV-infected mice. ZIKV RNA is absent at day 3 PI (d), present in cerebral cortex at day 6 PI (e), and in hippocampus plus cerebral cortex at day 10 PI (f). Scale bar represents 50 μm.