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. 2018 Jan 23;9(2):128–138. doi: 10.1007/s12672-017-0317-2

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© The Author(s) 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — Association of CYP19A1 mRNA expression with a, b rs10046 SNP genotype, c, d ER (estrogen receptor) status, and e, f ESR1 (estrogen receptor 1) mRNA expression. Analyses are in human primary breast tumors (a, c, e) and in human breast cancer cell lines (b, d, f). CC, CT, and TT are the genotypes of SNP rs10046. The numbers of patients and cell lines in each group (n) are shown in parentheses. The y-axes in a–f show normalized relative CYP19A1 mRNA levels (log(2) values). P values (P, in parentheses above each panel) were determined by a, b ANOVA, c, d unpaired, two-sided t tests, and e, f Spearman’s rank correlation. r, Spearman’s rho (rank correlation coefficient)