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. 2018 Mar 21;9:1180. doi: 10.1038/s41467-018-03410-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Overview of the JMJD5 structure. Topology (a) and ribbon representation (b) of the JMJD5.Mn.2OG complex and the active site close-up (c) (PDB: 6F4S). DSBH secondary structure elements are labelled I–VIII (green). The JMJD5 fold contains 7 α-helices, 13 β-strands and 3 3₁₀ helices. The N-terminal domain preceding the DSBH is in orange and the remainder of the structure, including the DSBH βIV–V insert, in light green. 2OG is shown by cyan sticks and the metal by a purple sphere