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. 2018 Mar 21;8:4935. doi: 10.1038/s41598-018-23003-3

Figure 2.

Figure 2

TBI-induced neuronal cell death in the cortex is decreased by intraperitoneal injection of 100 µg/kg Dex. Fluoro-Jade B (FJB) staining was performed to assess the neuronal cell death in the cortex that received saline or different concentrations of dexmedetomidine (Dex) treatment following moderate traumatic brain injury (TBI). (A) Schematic diagram of neuronal cell death counting. The regions enclosed by white lines were counting regions and the region enclosed by a red line was the region where higher magnification images were taken. (B) Neuronal cell death of saline treatment mice after TBI. (C) Neuronal cell death of 1 µg/kg Dex treatment mice after TBI. (D) Neuronal cell death of 10 µg/kg Dex treatment mice after TBI. (E) Neuronal cell death of 100 µg/kg Dex treatment mice after TBI. (F) Quantitative measurement of the neuronal cell death in the cortex. (n = 10, *p < 0.05).