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. 2018 Mar 21;8:4963. doi: 10.1038/s41598-018-23325-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Distribution of NDR values for the four combinations across the whole genome on HiSeq2000 (a) and Proton (b) platforms. Box plot represents NDR values in 124,011 windows for the same sample. x-axis is Chromosome number; y-axis is NDR values. The left and right represent the comparison without GC-correction and after GC-correction, respectively, for the same combination. The CV is the coefficient of variation of NDR across the whole genome. RS, RM, SS, SM are four combinations. RS is short for Rubicon PicoPLEX WGA Kit and single cell, RM is short for Rubicon PicoPLEX WGA Kit and multiple cells, SS is short for Sigma-Aldrich WGA4 kit and single cell, SM is short for Sigma-Aldrich WGA4 kit and multiple cells.