Table 1. Comparison of clinical parameters and histological findings in widely used mouse models of alcohol exposure and human AH patients.

	L-C diet	Gao-binge	“Hybrid” gastric infusion	Human AH patients
AST, U/L	Slight elevation	Elevated 100–300 U/L	Elevated 100–200 U/L	Elevated 80–120 U/L
ALT, U/L	Slight elevation	Elevated 100–300 U/L	Elevated 100–200 U/L	Mild elevation
Bilirubin	No increase	No increase	No increase	Elevated 3–30+ mg/dL
INR	No increase	No increase	No increase	Commonly elevated
Bilirubinostasis	None	None	None	Common
PMN infiltration	No increase	Significant	Significant	Significant
Fibrosis	None	None	None	Up to 98% of patients
Cirrhosis	None	None	None	Up to 80% of patients
Liver failure	None	Unknown	Unknown	ACLF

Abbreviations: ACLF, acute-on-chronic liver failure; AH, alcoholic hepatitis; ALT, alanine aminotransferase; AST, aspartate aminotransferase; INR, international normalized ratio; L-C Diet, liquid diet; PMN, polymorphonuclear cell.