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Timeline of available vaccines and influenza pandemics. Timeline of the major influenza virus pandemics from 1890 to 2017. Since the first isolation of an influenza virus in 1933, numerous vaccines have been developed and approved for use (white). Vaccines for pneumococcus (blue) and Hib (green), on the other hand, took nearly a century from the first isolation in 1881 and 1892, respectively.
