TABLE 3.

Seizure Management for 611 Neonates

Seizure Management	Preterm N = 92	Extremely Preterm (<28 weeks) N = 18	Very Preterm (28 to <32 weeks) N = 18	Moderate/Late Preterm (32 to <37 weeks) N = 56	P Value (Comparing Preterm Categories)	Term N = 519	P Value (Preterm Versus Term)
Initial loading antiseizure medication*					0.01		0.1
Phenobarbital	74 (88%)	12 (71%)	18 (100%)	44 (90%)		466 (94%)
Levetiracetam	9 (11%)	4 (24%)	0	5 (10%)		24 (5%)
Fosphenytoin	1 (1%)	1 (6%)	0	0		3 (< 1%)
Number of medications used	1 (1, 2)	1.5 (1, 3)	1 (1, 3)	1 (1, 2)	0.4	2 (1, 3)	0.003
Seizures refractory to initial load	54 (63%)	13 (76%)	11 (61%)	30 (60%)	0.6	319 (63%)	0.6
Discharged home on antiseizure medications†	31/46 (67%)	4/6 (67%)	6/10 (60%)	21/30 (70%)	0.8	294/382 (77%)	0.15

^*Among 580 neonates who received a loading dose of anti-seizure medication.

^†Among 428 neonates discharged to home.