Table 3.

Relative probability (relative risk) of response to treatment

Characteristic	Total N	Responders N(%)	p-Valuea	Crude risk ratio (95% CI)	Adjustedb risk ratio (95% CI)	Adjustedc risk ratio (95% CI)
Treatment sequence
Standard-standard, mechanism change	49	27 (55)	<0.001	2.26 (1.60, 3.22)	2.01 (1.46, 3.08)	2.25 (1.64, 3.35)
All other sequences	69	17 (25)		REF	REF	REF
Development
None/mild/moderate	49	23 (47)	0.06	1.59 (0.97, 2.78)	1.31 (0.79, 2.10)	-
Severe	67	20 (30)		REF	REF	-
Time to first treatment
Within 4 weeks	82	36 (44)	0.040	1.90 (1.05, 4.62)	-	1.82 (1.08, 4.10)
>4 weeks	34	8(24)		REF	-	REF

REF, reference group.

Relative risks estimated via logistic regression models using the method of Kleinman and Norton.³²

^aChi-square test.

^bModel including treatment sequence and development as covariates.

^cModel including treatment sequence and time to first treatment as covariates.