Table 4.
Characteristics by response to second spasm treatment
| Response to second treatment | |||
|---|---|---|---|
|
|
|||
| Characteristic | Response N = 44 |
Non-response N = 74 |
p-Valuea |
| Sex | |||
| Female | 18 (33) | 36 (67) | 0.42 |
| Male | 26(41) | 38 (59) | |
| Race | |||
| Black | 5(29) | 12 (71) | 0.58 |
| White | 31 (40) | 47 (60) | |
| Other | 4(29) | 10 (71) | |
| Ethnicity | |||
| Hispanic | 3(23) | 10 (77) | 0.20 |
| Non-Hispanic | 37(42) | 52 (58) | |
| Gestational age | |||
| <37 weeks | 9(35) | 17 (65) | 0.80 |
| At least 37 weeks | 34 (37) | 57 (63) | |
| Age at spasm onset | |||
| <12 months | 40 (39) | 63 (61) | 0.87 |
| At least 12 months | 4(36) | 7(64) | |
| First treatment to second treatment | |||
| Within 4 weeks | 21 (30) | 48 (70) | 0.12 |
| 4–8 weeks | 17(52) | 16 (49) | |
| >8 weeks | 6(38) | 10 (63) | |
| First spasm to second treatment | |||
| Within 3 weeks | 5(29) | 12 (71) | 0.17 |
| 3–6 weeks | 19 (50) | 19 (50) | |
| >6 weeks | 20 (33) | 41 (67) | |
| Prior seizures | |||
| Yes | 18 (39) | 28 (61) | 0.74 |
| No | 26 (36) | 46 (64) | |
| History of AED use | |||
| Yes | 18 (37) | 31 (63) | 0.92 |
| No | 26 (38) | 43 (62) | |
| Etiology | |||
| Genetic/metabolic/unknown abnormal | 17(30) | 39 (70) | 0.16 |
| Prior brain injury/MCD/other structural | 19 (40) | 29 (60) | |
| Unknown normal | 8 (57) | 6(43) | |
MCD, malformation of cortical development.
Values are N (row %).
a
Chi-square test.
The following variables had missing values: race (9), ethnicity (16), gestational age (1), age at spasm onset (4), time between first spasm and treatment start (2), time between first spasm and second treatment start (2), and development (2).